Bioactive

Power of the Nature

Bioactive is a multipurpose material obtained by processing and final lyophilization of the bovine amniotic membrane. It is used in cosmetics, wound treatment and veterinary medicine.

100% natural

More than 120 bioactive substances

Unique 3D structure

1 new life = 10g Bioactive

The story of bioactive

The EnVia P&S company was established by a combination of enthusiasm, high expertise and long-term work of the owner and the chief executive in one person, MUDr. Šárka Sekorova.

Thanks to her several years of operation in one of the largest tissue establishments in Europe, among other objects, she came into close contact with allogeneic tissue transplants, the source were human perinatal tissues, specifically the amniotic membrane. She soon found out that the possibilities of use are much more diverse than the current indications and focused its attention on the use of the amniotic membrane in the treatment of chronic wounds.

Over time, however, she has come to the conclusion that the potential of the human amniotic membrane is great, but there are some disadvantages as relatively difficult availability, cost of its manufacturing process and legislative requirements resulting from the fact that it is a category of human tissues and cells. So she began to look for ways to provide material with the same regenerative and healing capabilities, but more resource-efficient and economically affordable.

The answer to these questions seems to be the amniotic membrane of bovine origin. The company focuses mainly on the development and possibilities of using the bovine amniotic membrane in practice.

Amniotic membrane

  • part of the embryonic envelope
  • protects the fetus in the uterus
  • avascular tissue
  • contains a large amount of collagen, elastin, cytokines, growth factors and other bioactive substances

Amniotic membrane in cosmetics

  • supports regeneration
  • reduces the formation of wrinkles
  • supports skin elasticity
  • moisturizes the skin
  • reduces scarring
  • strengthens nails
  • nourishes and strengthens hair follicles
  • has overall anti-aging properties

Amniotic membrane in the treatment of wounds and burns

  • has significant healing effects
  • supports epithelialization
  • reduces pain
  • reduces the formation of adhesions
  • has anti-inflammatory effects
  • reduces the formation of scars in the wound
  • reduces infection in the wound

Amniotic membrane in veterinary medicine

  • has significant healing effects
  • supports epithelialization
  • reduces pain
  • reduces the formation of adhesions
  • has anti-inflammatory effects
  • reduces the formation of scars in the wound
  • reduces infection in the wound
  • can be used in the form of cream, gel, dusting powder or lyophilized / frozen plates in different sizes according to the current indication

Mechanism of the effect of the amnium membrane

The amniotic sac is composed of the amniotic and chorionic layers, which are constantly transformed by synthesis and degradation during the prenatal period of the fetus. The amniotic layer is a thin avascular membrane that consists of an epithelium, a basement membrane, a compact layer, and a fibroblast layer. Each of the layers contains many ECM macromolecules (e.g, type I and IV collagen, fibronectin, laminin, heparan sulfate, hyaluronic acid, and glycoproteins) that provide mechanical tissue support and provide sites for cell binding and motility. During pregnancy, the ECM of the amniotic membrane undergoes physiological remodeling – a highly coordinated process involving the secretion of growth factors, cytokines and matrix proteins – in order to maintain structural integrity and allow expansion during fetal growth.

As in response to injury, the balance of MMPs and their inhibitors is crucial for maintaining ECM during pregnancy. Another important factor is the presence of stem cells, which act on the surrounding tissues by their paracrine activity. Our knowledge about the functioning of the bovine amniotic membrane is based on knowledge of the processing, mechanism of action and subsequent use of the human amniotic membrane. The bioactive molecules contained in the processed material positively regulate cell proliferation and migration. Cytokines and growth factors can trigger signaling pathways that are helpful in shortening healing time while maximizing regenerative potential. These bioactive molecules promote cell proliferation and cell differentiation.

Mechanism of action of the amniotic membrane in the wound healing

  • facilitates the migration of epithelial cells
  • strengthens cell adhesion to the basement membrane
  • supports epithelial differentiation
  • has anti-inflammatory effects
  • reduces scarring
  • has bacteriostatic effects
  • is not immunogenic
  • performs a barrier function
  • contains the following cytokines and growth factors: bFGF, EGF, HGF, NGF, PDGF, IGF – 1, VEGF, TGF – ß1, TIMPs, interleukins, endostatin, collagen, elastin